The inner workings of an ancient biological clock.
Trends Biochem Sci
; 49(3): 236-246, 2024 03.
Article
en En
| MEDLINE
| ID: mdl-38185606
ABSTRACT
Circadian clocks evolved in diverse organisms as an adaptation to the daily swings in ambient light and temperature that derive from Earth's rotation. These timing systems, based on intracellular molecular oscillations, synchronize organisms' behavior and physiology with the 24-h environmental rhythm. The cyanobacterial clock serves as a special model for understanding circadian rhythms because it can be fully reconstituted in vitro. This review summarizes recent advances that leverage new biochemical, biophysical, and mathematical approaches to shed light on the molecular mechanisms of cyanobacterial Kai proteins that support the clock, and their homologues in other bacteria. Many questions remain in circadian biology, and the tools developed for the Kai system will bring us closer to the answers.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Cianobacterias
/
Relojes Circadianos
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos