Intravenous thrombolysis for ischemic stroke in the posterior circulation: A systematic review and meta-analysis.
J Stroke Cerebrovasc Dis
; 33(5): 107641, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38395096
ABSTRACT
OBJECTIVES:
Intravenous thrombolysis (IVT) is recommended in patients with ischemic stroke in the anterior and posterior circulation. Neurological outcomes due to posterior circulation strokes (PCS) without treatment remain poor. Our aim was to overview the literature on outcomes of IVT and conservative treatment in PCS, based on a systematic review and meta-analysis.METHODS:
A systematic literature search was performed on February 27th 2023. Outcome measures included favorable functional outcome at 90 days (modified Rankin Scale [mRS] 0-2), mortality at 90 days, and symptomatic intracranial hemorrhages (sICH). Weighted averages with DerSimonian-Laird approach was used to analyze the data. Subgroup analyses by time window were performed standard time window (<4.5 hours after symptom onset) and extended time window (>4.5 hours). Analyses were performed using R.RESULTS:
Eight prospective and four retrospective cohort studies were included (n = 1589 patients); no studies with conservative treatment were eligible. The pooled weighted probability regarding favorable functional outcome after IVT was 63 % (95 %CI0.45-0.78), for mortality 19 % (95 %CI0.11-0.30), and for sICH 4 % (95 %CI0.02-0.07). Subgroup analyses showed higher probabilities on achieving favorable functional outcomes for patients treated in the standard (77 %; 95 %CI0.62-0.88) compared to the extended time window (38 %; 95 %CI0.29-0.48) with RR = 1.93 (95 %CI1.66-2.24). Lower probabilities regarding mortality at 90 days and sICH were seen in patients treated in standard compared to extended time window (RR = 0.42, 95 %CI0.34-0.51 and RR = 0.27, 95 %CI0.16-0.45, respectively).CONCLUSIONS:
IVT in patients with PCS seems to be safe and effective in standard and extended time window. The effect of IVT is higher in the standard time window.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Terapia Trombolítica
/
Recuperación de la Función
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Fibrinolíticos
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Tiempo de Tratamiento
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Accidente Cerebrovascular Isquémico
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Stroke Cerebrovasc Dis
Asunto de la revista:
ANGIOLOGIA
/
CEREBRO
Año:
2024
Tipo del documento:
Article