Your browser doesn't support javascript.
loading
HIV-1 envelope diversity and sensitivity to broadly neutralizing antibodies across stages of acute HIV-1 infection.
VanderVeen, Laurie A; Selzer, Lisa; Moldt, Brian; Parvangada, Aiyappa; Li, Jiani; Ananworanich, Jintanat; Crowell, Trevor A; Eron, Joseph J; Daar, Eric S; Haubrich, Richard; Geleziunas, Romas; Cyktor, Joshua; Mellors, John W; Callebaut, Christian.
Afiliación
  • VanderVeen LA; Gilead Sciences, Inc., Foster City, CA, USA.
  • Selzer L; Gilead Sciences, Inc., Foster City, CA, USA.
  • Moldt B; Gilead Sciences, Inc., Foster City, CA, USA.
  • Parvangada A; GSK Vaccines, Rixensart, Belgium (Current).
  • Li J; Gilead Sciences, Inc., Foster City, CA, USA.
  • Ananworanich J; Gilead Sciences, Inc., Foster City, CA, USA.
  • Crowell TA; Amsterdam University Medical Centers, and Department of Global Health, Amsterdam Institute for Global Health & Development, Amsterdam, Netherlands.
  • Eron JJ; U.S. Military HIV Research Program at Walter Reed Army Institute of Research, Silver Spring, and The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD.
  • Daar ES; University of North Carolina at Chapel Hill, NC.
  • Haubrich R; The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA.
  • Geleziunas R; Gilead Sciences, Inc., Foster City, CA, USA.
  • Cyktor J; Gilead Sciences, Inc., Foster City, CA, USA.
  • Mellors JW; University of Pittsburgh, Pennsylvania, PA, USA.
  • Callebaut C; University of Pittsburgh, Pennsylvania, PA, USA.
AIDS ; 38(4): 607-610, 2024 03 15.
Article en En | MEDLINE | ID: mdl-38416554
ABSTRACT
We studied the relationship between viral diversity and susceptibility to broadly neutralizing antibodies (bNAbs) in longitudinal plasma and peripheral blood mononuclear cells from 89 people with HIV who initiated antiretroviral therapy (ART) during acute and early HIV-1 infection (AEHI). HIV-1 diversity and predicted bNAb susceptibility were comparable across AEHI. Diversity evolution was not observed during ART, suggesting (pro)viruses at initiation or during treatment may identify individuals with susceptible virus for bNAb interventional trials.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Seropositividad para VIH Límite: Humans Idioma: En Revista: AIDS Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Seropositividad para VIH Límite: Humans Idioma: En Revista: AIDS Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos