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DNA G-Quadruplex Is a Transcriptional Control Device That Regulates Memory.
Marshall, Paul R; Davies, Joshua; Zhao, Qiongyi; Liau, Wei-Siang; Lee, Yujin; Basic, Dean; Periyakaruppiah, Ambika; Zajaczkowski, Esmi L; Leighton, Laura J; Madugalle, Sachithrani U; Musgrove, Mason; Kielar, Marcin; Brueckner, Arie Maeve; Gong, Hao; Ren, Haobin; Walsh, Alexander; Kaczmarczyk, Lech; Jackson, Walker S; Chen, Alon; Spitale, Robert C; Bredy, Timothy W.
Afiliación
  • Marshall PR; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia paul.marshall@anu.edu.au t.bredy@uq.edu.au.
  • Davies J; Genome Sciences and Cancer Division & Eccles Institute of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia.
  • Zhao Q; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Liau WS; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Lee Y; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Basic D; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Periyakaruppiah A; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Zajaczkowski EL; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Leighton LJ; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Madugalle SU; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Musgrove M; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Kielar M; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Brueckner AM; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Gong H; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Ren H; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Walsh A; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Kaczmarczyk L; Cognitive Neuroepigenetics Laboratory, The Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
  • Jackson WS; Department of Biomedical and Clinical Sciences (BKV), Division of Neurobiology (NEURO), Linköping University, Linköping 581 83, Sweden.
  • Chen A; Department of Biomedical and Clinical Sciences (BKV), Division of Neurobiology (NEURO), Linköping University, Linköping 581 83, Sweden.
  • Spitale RC; Neurobiology of Stress Laboratory, Department Brain Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
  • Bredy TW; Department of Pharmaceutical Sciences, University of California Irvine, Irvine, California 92697.
J Neurosci ; 44(15)2024 Apr 10.
Article en En | MEDLINE | ID: mdl-38418220
ABSTRACT
The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here, we report that G-quadruplex DNA (G4-DNA) accumulates in neurons, in an experience-dependent manner, and that this is required for the transient silencing and activation of genes that are critically involved in learning and memory in male C57/BL6 mice. In addition, site-specific resolution of G4-DNA by dCas9-mediated deposition of the helicase DHX36 impairs fear extinction memory. Dynamic DNA structure states therefore represent a key molecular mechanism underlying memory consolidation.One-Sentence

Summary:

G4-DNA is a molecular switch that enables the temporal regulation of the gene expression underlying the formation of fear extinction memory.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: G-Cuádruplex Límite: Animals Idioma: En Revista: J Neurosci / J. neurosci / Journal of neuroscience Año: 2024 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: G-Cuádruplex Límite: Animals Idioma: En Revista: J Neurosci / J. neurosci / Journal of neuroscience Año: 2024 Tipo del documento: Article