Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway.
Chin Med J (Engl)
; 137(9): 1044-1053, 2024 May 05.
Article
en En
| MEDLINE
| ID: mdl-38445370
ABSTRACT
ABSTRACT Over the past decade, mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney disease. However, the precise molecular mechanisms linking mitochondrial damage to kidney disease remain elusive. The recent insights into the cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthetase (cGAS)-stimulator of interferon gene (STING) signaling pathway have revealed its involvement in many renal diseases. One of these findings is that mitochondrial DNA (mtDNA) induces inflammatory responses via the cGAS-STING pathway. Herein, we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage, focusing specifically on the association between mtDNA release-activated cGAS-STING signaling and the development of kidney diseases. Furthermore, we summarize the latest findings of cGAS-STING signaling pathway in cell, with a particular emphasis on its downstream signaling related to kidney diseases. This review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway, kidney diseases, and mitochondrial dysfunction.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
ADN Mitocondrial
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Transducción de Señal
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Enfermedades Renales
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Proteínas de la Membrana
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Mitocondrias
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Nucleotidiltransferasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Chin Med J (Engl)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China