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Fluid Cognition Among Individuals With Systemic Lupus Erythematosus.
Plantinga, Laura C; Yazdany, Jinoos; Pearce, Bradley D; Hoge, Courtney; Dunlop-Thomas, Charmayne; Lim, S Sam; Drenkard, Cristina; Katz, Patricia P; Bowling, C Barrett.
Afiliación
  • Plantinga LC; University of California, San Francisco.
  • Yazdany J; University of California, San Francisco.
  • Pearce BD; Emory University, Atlanta, Georgia.
  • Hoge C; Emory University, Atlanta, Georgia.
  • Dunlop-Thomas C; Emory University, Atlanta, Georgia.
  • Lim SS; Emory University, Atlanta, Georgia.
  • Drenkard C; Emory University, Atlanta, Georgia.
  • Katz PP; University of California, San Francisco.
  • Bowling CB; Durham Veterans Affairs Medical Center and Duke University, Durham, North Carolina.
Arthritis Care Res (Hoboken) ; 76(8): 1121-1131, 2024 08.
Article en En | MEDLINE | ID: mdl-38528776
ABSTRACT

OBJECTIVE:

We sought to describe fluid cognition and its correlates among individuals with systemic lupus erythematosus (SLE).

METHODS:

Participants (n = 199) were recruited from a population-based cohort for a single study visit (October 2019 to May 2022). Fluid cognition was measured via the National Institutes of Health Toolbox Fluid Cognition Battery (including episodic memory, working memory, attention and inhibitory control, processing speed, and cognitive flexibility domains) and expressed as age-corrected standard scores (mean 100, SD 15). Potential impairment was defined as a standard score >1.5 SD below the mean. Descriptive statistics were calculated and associations of various participant characteristics with the potential fluid cognition impairment were assessed with multivariable logistic regression.

RESULTS:

Participants' mean age was 46.1 years; most were female (87.4%), Black (86.4%), and non-Hispanic (95.0%). The mean overall fluid cognition score was 87.2; of the individual domains, the participants' mean score was lowest on attention and inhibitory control (82.0). Working status (odds ratio [OR] 0.30, 95% confidence interval [CI] 0.14-0.64) and higher self-reported physical functioning (OR 0.46, 95% CI 0.28-0.75) and physical performance (OR 0.72, 95% CI 0.59-0.87) were associated with lower odds of fluid cognition impairment; lower educational attainment was associated with higher odds (OR 3.82, 95% CI 1.67-8.75). Self-reported forgetfulness, neuropsychiatric damage, and depressive symptoms were not statistically significantly associated with potential impairment.

CONCLUSION:

Fluid cognition and, particularly, attention and inhibitory control were low in those with SLE relative to the general US population. Working status, higher physical functioning and performance, and higher educational attainment were associated with lower prevalence of potential impairment. Future work is needed to develop and implement interventions to help support cognition in individuals with SLE.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cognición / Disfunción Cognitiva / Lupus Eritematoso Sistémico Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arthritis Care Res (Hoboken) Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cognición / Disfunción Cognitiva / Lupus Eritematoso Sistémico Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Arthritis Care Res (Hoboken) Asunto de la revista: REUMATOLOGIA Año: 2024 Tipo del documento: Article