First imported case of Candida auris infection in Milan, Italy: genomic characterisation.
Infection
; 52(4): 1633-1638, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38557967
ABSTRACT
PURPOSE:
Candida auris, an emerging multidrug-resistant yeast, has been reported worldwide. In Italy, the first case was reported in 2019. We describe the first case of C. auris, imported from Greece, in Milan, using whole genome sequencing to characterise mutations associated with antifungal resistance. CASE PRESENTATION On October 2022 an 80-year-old Italian man was hospitalised in Greece. In the absence of clinical improvement, the patient was transferred to our hospital, in Italy, where blood culture resulted positive for C. auris. Despite therapy, the patient died of septic shock. In a phylogenetic analysis the genome was assigned to Clade I with strains from Kenya, United Arab Emirates and India. D1/D2 region resulted identical to a Greek strain, as for many other strains from different World regions, highlighting the diffusion of this strain.CONCLUSION:
Importation of C. auris from abroad has been previously described. We report the first case of C. auris imported into Italy from Greece, according to phylogenetic analysis. This case reinforces the need for monitoring critically ill hospitalised patients also for fungi and addresses the need for the standardisation of susceptibility testing and strategies for diagnosis and therapy.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Filogenia
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Candidiasis
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Candida auris
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Antifúngicos
Límite:
Aged80
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Humans
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Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Infection
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia