Iodine-Promoted Reductive Sulfenylation Using Ketones as Hydride Donors.
J Org Chem
; 89(8): 5851-5856, 2024 Apr 19.
Article
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| MEDLINE
| ID: mdl-38587835
ABSTRACT
Herein, an iodine-promoted reductive sulfenylation reaction of ketones with disulfides has been developed. This method provides an approach for synthesizing unsymmetrical alkyl-alkyl and alkyl-aryl sulfides in a single step. Investigation of the reaction mechanism revealed that ketones play a dual role in this process. They react with disulfides to produce vinyl thioethers and act as effective organic hydride donors, reducing the number of vinyl thioethers that are formed in situ. This study expands the range of applications of ketones in chemical synthesis.
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01-internacional
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MEDLINE
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En
Revista:
J Org Chem
Año:
2024
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Article