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Hypothalamic neuronal activation in non-human primates drives naturalistic goal-directed eating behavior.
Ha, Leslie Jaesun; Yeo, Hyeon-Gu; Kim, Yu Gyeong; Baek, Inhyeok; Baeg, Eunha; Lee, Young Hee; Won, Jinyoung; Jung, Yunkyo; Park, Junghyung; Jeon, Chang-Yeop; Kim, Keonwoo; Min, Jisun; Song, Youngkyu; Park, Jeong-Heon; Nam, Kyung Rok; Son, Sangkyu; Yoo, Seng Bum Michael; Park, Sung-Hyun; Choi, Won Seok; Lim, Kyung Seob; Choi, Jae Yong; Cho, Jee-Hyun; Lee, Youngjeon; Choi, Hyung Jin.
Afiliación
  • Ha LJ; Department of Biomedical Sciences, Neuroscience Research Institute, Wide River Institute of Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Yeo HG; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; KRIBB School of Bioscience, Korea National University of Science and Technology, Daejeon, Republic of Korea.
  • Kim YG; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; KRIBB School of Bioscience, Korea National University of Science and Technology, Daejeon, Republic of Korea.
  • Baek I; Department of Biomedical Sciences, Neuroscience Research Institute, Wide River Institute of Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Baeg E; Department of Nano-bioengineering, Incheon National University, Incheon, Republic of Korea; Center for Brain-Machine Interface, Incheon National University, Incheon, Republic of Korea.
  • Lee YH; Department of Biomedical Sciences, Neuroscience Research Institute, Wide River Institute of Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea.
  • Won J; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.
  • Jung Y; Department of Biomedical Sciences, Neuroscience Research Institute, Wide River Institute of Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of K
  • Park J; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.
  • Jeon CY; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.
  • Kim K; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, Republic of Korea.
  • Min J; Department of Biomedical Sciences, Neuroscience Research Institute, Wide River Institute of Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of K
  • Song Y; Center for Bio-imaging and Translational Research, Korea Basic Science Institute, Cheongju, Republic of Korea.
  • Park JH; Center for Bio-imaging and Translational Research, Korea Basic Science Institute, Cheongju, Republic of Korea.
  • Nam KR; Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
  • Son S; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea; Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea.
  • Yoo SBM; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea; Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea; Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea.
  • Park SH; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.
  • Choi WS; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.
  • Lim KS; Futuristic Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea.
  • Choi JY; Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea; Radiological and Medico-Oncological Sciences, Korea National University of Science and, Technology, Seoul, Republic of Korea. Electronic address: smhany@kirams.re.kr.
  • Cho JH; Center for Bio-imaging and Translational Research, Korea Basic Science Institute, Cheongju, Republic of Korea. Electronic address: jhcho@kbsi.re.kr.
  • Lee Y; National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Republic of Korea; KRIBB School of Bioscience, Korea National University of Science and Technology, Daejeon, Republic of Korea. Electronic address: neurosci@kribb.re.kr.
  • Choi HJ; Department of Biomedical Sciences, Neuroscience Research Institute, Wide River Institute of Immunology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Brain and Cognitive Sciences, Seoul National University, Seoul, South Korea. Electronic address: hjchoi@snu.a
Neuron ; 112(13): 2218-2230.e6, 2024 Jul 03.
Article en En | MEDLINE | ID: mdl-38663401
ABSTRACT
Maladaptive feeding behavior is the primary cause of modern obesity. While the causal influence of the lateral hypothalamic area (LHA) on eating behavior has been established in rodents, there is currently no primate-based evidence available on naturalistic eating behaviors. We investigated the role of LHA GABAergic (LHAGABA) neurons in eating using chemogenetics in three macaques. LHAGABA neuron activation significantly increased naturalistic goal-directed behaviors and food motivation, predominantly for palatable food. Positron emission tomography and magnetic resonance spectroscopy validated chemogenetic activation. Resting-state functional magnetic resonance imaging revealed that the functional connectivity (FC) between the LHA and frontal areas was increased, while the FC between the frontal cortices was decreased after LHAGABA neuron activation. Thus, our study elucidates the role of LHAGABA neurons in eating and obesity therapeutics for primates and humans.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Conducta Alimentaria / Objetivos Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Conducta Alimentaria / Objetivos Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2024 Tipo del documento: Article