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Treg-Derived Extracellular Vesicles: Roles in Diseases and Theranostics.
Wu, Tingting; Wang, Lulu; Gao, Chen; Jian, Chen; Liu, Yajing; Fu, Zhiwen; Shi, Chen.
Afiliación
  • Wu T; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Wang L; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan, 430022, China.
  • Gao C; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Jian C; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan, 430022, China.
  • Liu Y; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
  • Fu Z; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan, 430022, China.
  • Shi C; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Mol Pharm ; 21(6): 2659-2672, 2024 Jun 03.
Article en En | MEDLINE | ID: mdl-38695194
ABSTRACT
Regulatory T cells (Tregs), a subset of CD4+ T cells, are indispensable in maintaining immune self-tolerance and have been utilized in various diseases. Treg-derived extracellular vesicles (Treg-EVs) have been discovered to play an important role in the mechanism of Treg functions. As cell-derived membranous particles, EVs carry multiple bioactive substances that possess tremendous potential for theranostics. Treg-EVs are involved in numerous physiological and pathological processes, carrying proteins and miRNAs inherited from the parental cells. To comprehensively understand the function of Treg-EVs, here we reviewed the classification of Treg-EVs, the active molecules in Treg-EVs, their various applications in diseases, and the existing challenges for Treg-EVs based theranostics. This Review aims to clarify the feasibility and potential of Treg-EVs in diseases and theranostics, facilitating further research and application of Treg-EVs.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos T Reguladores / Vesículas Extracelulares Límite: Animals / Humans Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Linfocitos T Reguladores / Vesículas Extracelulares Límite: Animals / Humans Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China