Novel MRI and histopathological findings in a young Bullmastiff cross dog with mitochondrial fission encephalopathy.
Vet Radiol Ultrasound
; 2024 May 06.
Article
en En
| MEDLINE
| ID: mdl-38706372
ABSTRACT
A 9-month-old male Bullmastiff cross dog was presented with a history of progressive proprioceptive ataxia and behavior changes. Neuroanatomical localization was multifocal with forebrain and vestibulo-cerebellum involvement. MRI identified moderate diffuse cerebral sulci widening, dilation of the ventricular system, and rounded, well-defined, bilaterally symmetrical T2W, FLAIR, and T2* hyperintense intra-axial lesions affecting the olivary nuclei. Histopathological examination was indicative of a primary mitochondrial disorder. This was confirmed following genetic analysis which identified mitochondrial fission encephalopathy with a homozygous frameshift variant in the MFF gene. This case report documents diagnostic imaging and histopathological findings not previously reported in dogs affected with mitochondrial fission encephalopathy, suggesting a different selective regional vulnerability of the neurons.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Vet Radiol Ultrasound
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
MEDICINA VETERINARIA
/
RADIOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Reino Unido