Clinical characteristics of systemic lupus erythematosus patients with adrenal hemorrhage.
Clin Rheumatol
; 43(7): 2223-2227, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38724818
ABSTRACT
INTRODUCTION:
Adrenal hemorrhage (AH) is a rare condition and severe cases can lead to acute adrenal insufficiency with potentially life-threatening consequences. AH can be caused by a variety of etiologic factors, including systemic lupus erythematosus and antiphospholipid syndrome (APS). The early identification and treatment of these patients improves their prognosis.OBJECTIVE:
The aims of this study were to analyze and summarize the clinical characteristics of systemic lupus erythematosus patients with AH.METHODS:
The clinical characteristics of 6 systemic lupus erythematosus patients complicated with AH admitted to Peking Union Medical College Hospital and Beijing Shijitan Hospital from May 2004 to April 2022 were retrospectively analyzed.RESULTS:
The diagnosis of AH was based on computed tomography (CT) findings. Two patients had bilateral lesions, and the other 4 patients had unilateral lesions. The symptoms of adrenal insufficiency were observed in 2 patients. The frequent presenting symptoms were abdominal pain, lower abdominal distension, vomiting, weakness, fever, arthrodynia, and skin rash. Four patients had APS. Five patients (4 patients with APS and 1 patient without APS) had thromboembolic events. All patients received glucocorticoid and immunosuppressant therapy. Five patients were treated with anticoagulant therapy. Follow-up imaging examinations showed a partial or total regression of the lesions after treatment.CONCLUSIONS:
In the proper clinical setting, having high clinical suspicion for AH, early diagnosis and timely management is crucial to avoid life-threatening adrenal insufficiency. Key Points ⢠AH is a rare condition and severe cases may lead to death. It can be caused by a variety of etiologic factors, including SLE. ⢠In patients with SLE, especially combined with APS, if they complain of abdominal pain, particularly when common gastrointestinal involvement is difficult to explain, a high index of clinical suspicion is needed for the diagnosis of AH. ⢠Early identification of AH in SLE patients can improve their prognosis.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tomografía Computarizada por Rayos X
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Hemorragia
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Lupus Eritematoso Sistémico
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Rheumatol
Año:
2024
Tipo del documento:
Article
País de afiliación:
China