Two new jatrophane diterpenoids from Euphorbia helioscopia with activity towards autophagic flux.
J Asian Nat Prod Res
; 26(8): 900-909, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38753580
ABSTRACT
Nine jatrophane diterpenoids were isolated from the whole plant Euphorbia helioscopia, including two new ones, helioscopnins A (1) and B (2). Comprehensive spectroscopic data analysis and ECD calculations elucidated their structures, including absolute configurations. All compounds were evaluated for bioactivity towards autophagic flux by flow cytometry using HM mCherry-GFP-LC3 cells. Compounds 1, 3, 4, 5, 8, and 9 significantly increased autophagic flux.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Autofagia
/
Euphorbia
/
Diterpenos
Límite:
Humans
Idioma:
En
Revista:
J Asian Nat Prod Res
/
J. Asian nat. prod. res. (Online)
/
Journal of Asian natural products research (Online)
Asunto de la revista:
BOTANICA
/
QUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China