Your browser doesn't support javascript.
loading
Neutrophils in Cancer immunotherapy: friends or foes?
Huang, Xueqin; Nepovimova, Eugenie; Adam, Vojtech; Sivak, Ladislav; Heger, Zbynek; Valko, Marian; Wu, Qinghua; Kuca, Kamil.
Afiliación
  • Huang X; College of Life Science, Yangtze University, Jingzhou, 434025, China.
  • Nepovimova E; Department of Chemistry, Faculty of Science, University of Hradec Králové, 500 03, Hradec Králové, Czech Republic.
  • Adam V; Department of Chemistry and Biochemistry, Mendel University in Brno, 613 00, Brno, Czech Republic.
  • Sivak L; Department of Chemistry and Biochemistry, Mendel University in Brno, 613 00, Brno, Czech Republic.
  • Heger Z; Department of Chemistry and Biochemistry, Mendel University in Brno, 613 00, Brno, Czech Republic.
  • Valko M; Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37, Bratislava, Slovakia.
  • Wu Q; College of Life Science, Yangtze University, Jingzhou, 434025, China. wqh212@hotmail.com.
  • Kuca K; Department of Chemistry, Faculty of Science, University of Hradec Králové, 500 03, Hradec Králové, Czech Republic. wqh212@hotmail.com.
Mol Cancer ; 23(1): 107, 2024 May 18.
Article en En | MEDLINE | ID: mdl-38760815
ABSTRACT
Neutrophils play a Janus-faced role in the complex landscape of cancer pathogenesis and immunotherapy. As immune defense cells, neutrophils release toxic substances, including reactive oxygen species and matrix metalloproteinase 9, within the tumor microenvironment. They also modulate the expression of tumor necrosis factor-related apoptosis-inducing ligand and Fas ligand, augmenting their capacity to induce tumor cell apoptosis. Their involvement in antitumor immune regulation synergistically activates a network of immune cells, bolstering anticancer effects. Paradoxically, neutrophils can succumb to the influence of tumors, triggering signaling cascades such as JAK/STAT, which deactivate the immune system network, thereby promoting immune evasion by malignant cells. Additionally, neutrophil granular constituents, such as neutrophil elastase and vascular endothelial growth factor, intricately fuel tumor cell proliferation, metastasis, and angiogenesis. Understanding the mechanisms that guide neutrophils to collaborate with other immune cells for comprehensive tumor eradication is crucial to enhancing the efficacy of cancer therapeutics. In this review, we illuminate the underlying mechanisms governing neutrophil-mediated support or inhibition of tumor progression, with a particular focus on elucidating the internal and external factors that influence neutrophil polarization. We provide an overview of recent advances in clinical research regarding the involvement of neutrophils in cancer therapy. Moreover, the future prospects and limitations of neutrophil research are discussed, aiming to provide fresh insights for the development of innovative cancer treatment strategies targeting neutrophils.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microambiente Tumoral / Inmunoterapia / Neoplasias / Neutrófilos Límite: Animals / Humans Idioma: En Revista: Mol Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Microambiente Tumoral / Inmunoterapia / Neoplasias / Neutrófilos Límite: Animals / Humans Idioma: En Revista: Mol Cancer Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article País de afiliación: China