Ferritinophagy and Ferroptosis in Cerebral Ischemia Reperfusion Injury.
Neurochem Res
; 49(8): 1965-1979, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38834843
ABSTRACT
Cerebral ischemia-reperfusion injury (CIRI) is the second leading cause of death worldwide, posing a huge risk to human life and health. Therefore, investigating the pathogenesis underlying CIRI and developing effective treatments are essential. Ferroptosis is an iron-dependent mode of cell death, which is caused by disorders in iron metabolism and lipid peroxidation. Previous studies demonstrated that ferroptosis is also a form of autophagic cell death, and nuclear receptor coactivator 4(NCOA4) mediated ferritinophagy was found to regulate ferroptosis by interfering with iron metabolism. Ferritinophagy and ferroptosis are important pathogenic mechanisms in CIRI. This review mainly summarizes the link and regulation between ferritinophagy and ferroptosis and further discusses their mechanisms in CIRI. In addition, the potential treatment methods targeting ferritinophagy and ferroptosis for CIRI are presented, providing new ideas for the prevention and treatment of clinical CIRI in the future.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión
/
Ferritinas
/
Ferroptosis
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neurochem Res
Año:
2024
Tipo del documento:
Article
País de afiliación:
China