Blood metabolites mediate the causal relationship between circulating CX3CL1 levels and prostate cancer: A 2-step Mendelian randomization study.
Medicine (Baltimore)
; 103(23): e38433, 2024 Jun 07.
Article
en En
| MEDLINE
| ID: mdl-38847691
ABSTRACT
Chemokines influence the progression of prostate cancer (PCa) through multiple mechanisms. However, the effect of C-X3-C chemokine ligand 1 (CX3CL1) on PCa risk remains controversial. Our study aimed to investigate whether circulating CX3CL1 is causally associated with PCa and to identify metabolites that have mediating effects using the 2-step bidirectional Mendelian randomization (MR) analysis process. Inverse variance weighting (IVW) results were used as the primary observations, while additional sensitivity analyses were conducted. For each standard deviation increase exhibited by the circulating CX3CL1 levels, the risk of PCa was reduced by 0.4% (IVW ORâ
=â
0.996, [95% CIâ
=â
0.994-0.998], Pâ
<â
.001), and blood alliin levels increased by 19% (IVW ORâ
=â
1.185, [95% CIâ
=â
1.01-1.54], Pâ
=â
.003). For each standard deviation increase in the blood alliin levels, the risk of PCa was reduced by 0.1% (IVW ORâ
=â
0.999, [95% CIâ
=â
0.997-0.999], Pâ
=â
.03). Therefore, the protective effect of circulating CX3CL1 on PCa may be mediated by blood alliin levels (mediated proportionâ
=â
6.7%). The results supported the notion that high levels of circulating CX3CL1 indicate a lower PCa risk and the idea that the food-derived antioxidant alliin may mediate this association. We emphasize that the use of CX3CL1 as a protective factor against PCa may provide new strategies for PCa prevention and care in the future.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Quimiocina CX3CL1
/
Análisis de la Aleatorización Mendeliana
Límite:
Humans
/
Male
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China