Both intrinsic and microenvironmental factors contribute to the regulation of stem cell quiescence.
J Cell Physiol
; 239(8): e31325, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38860372
ABSTRACT
Precise regulation of stem cell quiescence is essential for tissue development and homeostasis. Therefore, its aberrant regulation is intimately correlated with various human diseases. However, the detailed mechanisms of stem cell quiescence and its specific role in the pathogenesis of various diseases remain to be determined. Recent studies have revealed that the intrinsic and microenvironmental factors are the potential candidates responsible for the orderly switch between the dormant and activated states of stem cells. In addition, defects in signaling pathways related to internal and external factors of stem cells might contribute to the initiation and development of diseases by altering the dormancy of stem cells. In this review, we focus on the mechanisms underlying stem cell quiescence, especially the involvement of intrinsic and microenvironmental factors. In addition, we discuss the relationship between the anomalies of stem cell quiescence and related diseases, hopefully providing therapeutic insights for developing novel treatments.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Células Madre
/
Transducción de Señal
/
Nicho de Células Madre
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Cell Physiol
Año:
2024
Tipo del documento:
Article
País de afiliación:
China