Isolation and target identification of antihepatoma polyprenylphenols from the edible mushroom Suillus granulatus.
Food Funct
; 15(14): 7430-7440, 2024 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-38904163
ABSTRACT
Eight polyprenylphenol derivatives were isolated from the wild edible mushroom Suillus granulatus, including seven novel compounds, named suillin F-L (2-8), and one previously identified compound (1). The structures of the new compounds were elucidated using HR-ESI-MS and 1D and 2D NMR data. The absolute configuration of compound 8 was assigned based on the comparison of the experimental and calculated ECD data. All isolated compounds were evaluated for their cytotoxicity against HepG2 cancer cell lines. Compounds 1 and 3-6 demonstrated significant antitumor activity compared to the positive control (cisplatin), with IC50 values ranging from 8.19 to 13.97 µM. Furthermore, DARTS assay and LC-MS/MS analysis were used to identify HSP90AA1 as the direct target of compound 5, and the interaction between compound 5 and HSP90AA1 was verified by molecular docking.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fenoles
/
Simulación del Acoplamiento Molecular
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Food Funct
Año:
2024
Tipo del documento:
Article
País de afiliación:
China