Metal-catalyzed Markovnikov-type selective hydrofunctionalization of terminal alkynes.
Chem Soc Rev
; 53(14): 7566-7589, 2024 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-38904176
ABSTRACT
Metal-catalyzed highly Markovnikov-type selective hydrofunctionalization of terminal alkynes provides a straightforward and atom-economical route to access 1,1-disubstituted alkenes, which have a wide range of applications in organic synthesis. However, the highly Markovnikov-type selective transformations are challenging due to the electronic and steric effects during the addition process. With the development of metal-catalyzed organic synthesis, different metal catalysts have been developed to solve this challenge, especially for platinum group metal catalysts. In this perspective, we review homogeneous metal-catalyzed Markovnikov-type selective hydrofunctionalization of terminal alkynes according to the classified element types as well as reaction mechanisms. Future avenues for investigation are also presented to help expand this exciting field.
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Chem Soc Rev
Año:
2024
Tipo del documento:
Article
País de afiliación:
China