Difficult-to-Treat Concept in Psoriatic Arthritis: Analysis of 2 Potential Definitions in a Large Group of Patients: A Cross-Sectional Study.
J Rheumatol
; 2024 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-39009395
ABSTRACT
OBJECTIVE:
The main aim of the study was to evaluate the performance of 2 proposed criteria for difficult-to-treat (D2T) psoriatic arthritis (PsA) in a group of patients and to evaluate the agreement between the 2 sets of criteria.METHODS:
We performed a cross-sectional analysis of 2 longitudinal cohorts of patients with PsA fulfilling the Classification Criteria for Psoriatic Arthritis (CASPAR), with at least 1 year of follow-up. A detailed medical history was collected and a physical examination was performed for all recruited patients. The proposed criteria for patients with D2T PsA were applied in our group. To test the performance of the 2 sets of criteria, we used an external validator (absence of patient acceptable symptom state + physician global assessment ≥ 6 cm). Finally, the agreement between the 2 sets of criteria was assessed.RESULTS:
We evaluated 378 patients with PsA (219 male/159 female), with a mean age (range) of 58 (19-75) years. Seventy-five (19.8%) patients fulfilled the D2T criteria proposed by Perrotta et al and 58 (15.3%) the D2T criteria proposed by Kumthekar et al. Both criteria showed comparable performance, with low sensitivity (Perrotta 37.8%, Kumthekar 29.7%) but good specificity (Perrotta 82.1%, Kumthekar 86.2%). Finally, the agreement between the 2 sets of criteria is substantial (Fleiss κ 0.72), suggesting that both criteria identify nearly the same group of patients.CONCLUSION:
Our study compared 2 published sets of criteria showing comparable performance and substantial agreement. This study may pave the way for further research in this field.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Rheumatol
Año:
2024
Tipo del documento:
Article