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Retinoic acid signalling regulates branchiomeric neck muscle development at the head/trunk interface.
Dumas, Camille E; Rousset, Célia; De Bono, Christopher; Cortés, Claudio; Jullian, Estelle; Lescroart, Fabienne; Zaffran, Stéphane; Adachi, Noritaka; Kelly, Robert G.
Afiliación
  • Dumas CE; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France.
  • Rousset C; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France.
  • De Bono C; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France.
  • Cortés C; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France.
  • Jullian E; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France.
  • Lescroart F; Aix-Marseille Université, INSERM, MMG U1251, 13005 Marseille, France.
  • Zaffran S; Aix-Marseille Université, INSERM, MMG U1251, 13005 Marseille, France.
  • Adachi N; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France.
  • Kelly RG; Aix-Marseille Université, CNRS UMR 7288, IBDM, 13009 Marseille, France.
Development ; 151(16)2024 Aug 15.
Article en En | MEDLINE | ID: mdl-39082789
ABSTRACT
Skeletal muscles of the head and trunk originate in distinct lineages with divergent regulatory programmes converging on activation of myogenic determination factors. Branchiomeric head and neck muscles share a common origin with cardiac progenitor cells in cardiopharyngeal mesoderm (CPM). The retinoic acid (RA) signalling pathway is required during a defined early time window for normal deployment of cells from posterior CPM to the heart. Here, we show that blocking RA signalling in the early mouse embryo also results in selective loss of the trapezius neck muscle, without affecting other skeletal muscles. RA signalling is required for robust expression of myogenic determination factors in posterior CPM and subsequent expansion of the trapezius primordium. Lineage-specific activation of a dominant-negative RA receptor reveals that trapezius development is not regulated by direct RA signalling to myogenic progenitor cells in CPM, or through neural crest cells, but indirectly through the somitic lineage, closely apposed with posterior CPM in the early embryo. These findings suggest that trapezius development is dependent on precise spatiotemporal interactions between cranial and somitic mesoderm at the head/trunk interface.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tretinoina / Transducción de Señal / Desarrollo de Músculos / Cabeza / Mesodermo / Músculos del Cuello Límite: Animals Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Francia

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tretinoina / Transducción de Señal / Desarrollo de Músculos / Cabeza / Mesodermo / Músculos del Cuello Límite: Animals Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Francia