Fibroblast growth factor homologous factors: canonical and non-canonical mechanisms of action.
J Physiol
; 602(17): 4097-4110, 2024 Sep.
Article
en En
| MEDLINE
| ID: mdl-39083261
ABSTRACT
Since their discovery nearly 30 years ago, fibroblast growth factor homologous factors (FHFs) are now known to control the functionality of excitable tissues through a range of mechanisms. Nervous and cardiac system dysfunctions are caused by loss- or gain-of-function mutations in FHF genes. The best understood 'canonical' targets for FHF action are voltage-gated sodium channels, and recent studies have expanded the repertoire of ways that FHFs modulate sodium channel gating. Additional 'non-canonical' functions of FHFs in excitable and non-excitable cells, including cancer cells, have been reported over the past dozen years. This review summarizes and evaluates reported canonical and non-canonical FHF functions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factores de Crecimiento de Fibroblastos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Physiol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos