Barley ß-glucan bioactive films: Promising eco-friendly materials for wound healing.
Int J Biol Macromol
; 278(Pt 2): 134434, 2024 Oct.
Article
en En
| MEDLINE
| ID: mdl-39098670
ABSTRACT
Mixtures containing ß-glucans were extracted from barley, under both mild and high alkaline conditions, to prepare biodegradable films (MA and HA, respectively), as natural dressings with intrinsic therapeutic properties. An in-depth characterization was performed to evaluate the impact of mild and high alkaline conditions on chemical, physicochemical, and biological features for potential use in wound treatments. Both MA and HA films exhibited a good ability to absorb water and simulate wound fluid, which helps maintain optimal tissue hydration. Moreover, their oxygen permeability (147.6 and 16.4â¯cm3â¯×⯵m/m2â¯×â¯24â¯hâ¯×â¯Paâ¯×â¯107, respectively) appeared adequate for the intended application. Biocompatibility tests showed that the films do not harm human dermal fibroblasts. Impressively, they promote cell attachment and growth, with MA having a stronger effect due to its higher ß-glucan content. Furthermore, MA films can modulate macrophage behaviour in an inflamed microenvironment, reducing oxidative stress and pro-inflammatory cytokines, while simultaneously increasing levels of anti-inflammatory cytokines. In a scratch test, HA films allowed for faster fibroblast migration within the first 16â¯h compared to MA. Overall, this study demonstrates that developing ß-glucan based films from barley, through a sustainable and cost-effective process, holds great promise for skin applications. These films exhibit significant potential to promote wound healing and modulate inflammation.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hordeum
/
Cicatrización de Heridas
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Materiales Biocompatibles
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Beta-Glucanos
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Fibroblastos
Límite:
Animals
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Humans
Idioma:
En
Revista:
Int J Biol Macromol
/
Int. j. biol. macromol
/
International journal of biological macromolecules
Año:
2024
Tipo del documento:
Article
País de afiliación:
Italia