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A molecular analysis of meropenem-vaborbactam non-susceptible KPC-producing Klebsiella pneumoniae.
Yasmin, Mohamad; Marshall, Steven H; Chen, Liang; Rhoads, Daniel D; Jacobs, Michael R; Rojas, Laura J; Perez, Federico; Hujer, Andrea M; Hujer, Kristine M; van Duin, David; Fowler, Vance; Chambers, Henry F; Kreiswirth, Barry N; Bonomo, Robert A.
Afiliación
  • Yasmin M; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Marshall SH; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Chen L; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
  • Rhoads DD; Department of Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA.
  • Jacobs MR; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Rojas LJ; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Perez F; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Hujer AM; Case Western Reserve University-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA.
  • Hujer KM; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • van Duin D; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Fowler V; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Chambers HF; Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Kreiswirth BN; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Bonomo RA; Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Antimicrob Agents Chemother ; : e0020824, 2024 Aug 20.
Article en En | MEDLINE | ID: mdl-39162528
ABSTRACT
We characterized the molecular determinants of meropenem-vaborbactam (MV) non-susceptibility among non-metallo-ß-lactamase-producing KPC-Klebsiella pneumoniae (KPC-KP). Whole-genome sequencing was performed to identify mutations associated with MV non-susceptibility. Isolates with elevated MV MICs were found to have mutations encoding truncated or altered OmpK36 porins and increased blaKPC copy numbers. KPC-KP isolates with decreased susceptibility to MV were detected among a collection of isolates predating the availability of MV.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Antimicrob Agents Chemother Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Antimicrob Agents Chemother Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos