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Y and Mitochondrial Chromosomes in the Heterogeneous Stock Rat Population.
Okamoto, Faith; Chitre, Apurva S; Sanches, Thiago Missfeldt; Chen, Denghui; Munro, Daniel; Aron, Allegra T; Beeson, Angela; Bimschleger, Hannah V; Eid, Maya; Martinez, Angel G Garcia; Han, Wenyan; Holl, Katie; Jackson, Tyler; Johnson, Benjamin B; King, Christopher P; Kuhn, Brittany N; Lamparelli, Alexander C; Netzley, Alesa H; Nguyen, Khai-Minh H; Peng, Beverly F; Tripi, Jordan A; Wang, Tengfei; Ziegler, Kendra S; Adams, Douglas J; Baud, Amelie; Carrette, Lieselot L G; Chen, Hao; de Guglielmo, Giordano; Dorrestein, Pieter; George, Olivier; Ishiwari, Keita; Jablonski, Monica M; Jhou, Thomas C; Kallupi, Marsida; Knight, Rob; Meyer, Paul J; Woods, Leah C Solberg; Polesskaya, Oksana; Palmer, Abraham A.
Afiliación
  • Okamoto F; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
  • Chitre AS; Bioinformatics and System Biology Program, University of California San Diego, La Jolla, CA 92093, USA.
  • Sanches TM; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
  • Chen D; Bioinformatics and System Biology Program, University of California San Diego, La Jolla, CA 92093, USA.
  • Munro D; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
  • Aron AT; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
  • Beeson A; Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, USA.
  • Bimschleger HV; Department of Internal Medicine, Molecular Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
  • Eid M; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
  • Martinez AGG; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Han W; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Holl K; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Jackson T; Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
  • Johnson BB; Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • King CP; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
  • Kuhn BN; Department of Psychology, University at Buffalo, Buffalo, NY 14260, USA.
  • Lamparelli AC; Department of Neuroscience, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Netzley AH; Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Nguyen KH; Department of Emergency Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
  • Peng BF; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
  • Tripi JA; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
  • Wang T; Department of Psychology, University at Buffalo, Buffalo, NY 14260, USA.
  • Ziegler KS; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Adams DJ; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
  • Baud A; Department of Orthopedics, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Carrette LLG; Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
  • Chen H; Universitat Pompeu Fabra, Barcelona, Spain.
  • de Guglielmo G; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
  • Dorrestein P; Department of Pharmacology, Addiction Science and Toxicology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • George O; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
  • Ishiwari K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
  • Jablonski MM; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
  • Jhou TC; Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA.
  • Kallupi M; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093, USA.
  • Knight R; Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
  • Meyer PJ; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY 14203, USA.
  • Woods LCS; Clinical and Research Institute on Addictions, University at Buffalo, Buffalo, NY 14203, USA.
  • Polesskaya O; Department of Ophthalmology and Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
  • Palmer AA; Department of Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
G3 (Bethesda) ; 2024 Sep 09.
Article en En | MEDLINE | ID: mdl-39250761
ABSTRACT
Genome-wide association studies typically evaluate the autosomes and sometimes the X Chromosome, but seldom consider the Y or mitochondrial Chromosomes. We genotyped the Y and mitochondrial Chromosomes in heterogeneous stock rats (Rattus norvegicus), an outbred population created from eight inbred strains. We identified 8 distinct Y and 4 distinct mitochondrial Chromosomes among the 8 founders. However, only two types of each nonrecombinant chromosome were observed in our modern heterogeneous stock rat population (generations 81-97). Despite the relatively large sample size, there were virtually no significant associations for behavioral, physiological, metabolome, or microbiome traits after correcting for multiple comparisons. However, both Y and mitochondrial Chromosomes were strongly associated with expression of a few genes located on those chromosomes, which provided a positive control. Our results suggest that within modern heterogeneous stock rats there are no Y and mitochondrial Chromosomes differences that strongly influence behavioral or physiological traits. These results do not address other ancestral Y and mitochondrial Chromosomes that do not appear in modern heterogeneous stock rats, nor do they address effects that may exist in other rat populations, or in other species.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: G3 (Bethesda) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: G3 (Bethesda) Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos