Location and chemical synthesis of a pre-S gene coded immunodominant epitope of hepatitis B virus.
Science
; 224(4647): 392-5, 1984 Apr 27.
Article
en En
| MEDLINE
| ID: mdl-6200931
ABSTRACT
Immunodominant, disulfide-bond independent epitopes recognized by human antibodies to hepatitis B virus (HBV) are located within the 55-residue amino terminal portion (coded for by the pre-S region of HBV DNA) of minor HBV envelope components larger than the major protein constituents encoded by the S gene. A peptide having the sequence of the first 26 amino acids from the amino terminal methionine was synthesized and elicited antibodies (at dilutions of greater than or equal to 1 to 10(5) ) to the HBV envelope. These antibodies can be utilized for diagnostic tests. The immunogenicity of the peptide was substantially increased by covalent attachment to liposomes. The disulfide bond-independent determinants on sequences coded for by the pre-S gene may be more easily mimicked by peptide analogs than "conformational" determinants on the S-gene product.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Virus de la Hepatitis B
/
Genes Virales
/
Antígenos de Superficie de la Hepatitis B
/
Epítopos
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1984
Tipo del documento:
Article