The malaria parasite monitored by photoacoustic spectroscopy.
Science
; 223(4638): 828-30, 1984 Feb 24.
Article
en En
| MEDLINE
| ID: mdl-6695185
ABSTRACT
Noninvasive photoacoustic spectroscopy was used to study the malaria parasites Plasmodium chabaudi and Plasmodium berghei, their pigment, and ferriprotoporphyrin IX, which is a by-product of the hemoglobin that the parasite ingests. The results indicate that the pigment consists of ferriprotophorphyrin self-aggregates and a noncovalent complex of ferriprotoporphyrin and protein. Spectra of chloroquine-treated parasites reveal in situ interaction between the drug and ferriprotoporphyrin. Chloroquine-resistant parasites, readily distinguishable by this method, appear to degrade hemoglobin only partially.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium
/
Análisis Espectral
/
Eritrocitos
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1984
Tipo del documento:
Article