Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments.
FEBS Lett
; 325(3): 167-72, 1993 Jul 05.
Article
en En
| MEDLINE
| ID: mdl-7686508
ABSTRACT
We previously reported that tau protein kinase I (TPKI) induced normal tau protein into a state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis using several antibodies. We also present the amino acid sequence of TPKI, which is identical to glycogen synthase kinase 3 beta (GSK3 beta). Moreover, we found that TPKI activity was inseparable from GSK3 activity throughout the purification procedure. These results indicate that TPKI is identical to GSK3 beta.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Proteínas Quinasas
/
Proteínas Serina-Treonina Quinasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
1993
Tipo del documento:
Article
País de afiliación:
Japón