The 2-5A system and HIV infection.
Prog Mol Subcell Biol
; 14: 176-97, 1994.
Article
en En
| MEDLINE
| ID: mdl-7914804
ABSTRACT
2',5'-Oligoadenylates (2-5A) have an essential role in the establishment of the antiviral state of a cell exposed to virus infection. The key enzymes of the 2-5A system are the 2-5A forming 2',5'-oligoadenylate synthetase (2-5OAS), the activity of which depends on the presence of viral or cellular double-stranded RNA (dsRNA), and the 2-5A-activated ribonuclease (RNase L). Basic research in recent years has shown that the 2-5A system is a promising target for anti-HIV chemotherapy, particularly due to its interaction with double-stranded segments within HIV RNA. Two new strategies have been developed which yield a selective antiviral effect of 2-5A against HIV-1 infection (1) development of 2-5A analogues displaying a dual mode of action (activation of RNase L and inhibition of HIV-1 RT) and (2) intracellular immunization of cells against HIV-1 infection by application of the HIV-1-LTR--2-5OAS hybrid gene. A further strategy is the inhibition of DNA topoisomerase I by longer 2-5A oligomers.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
Oligorribonucleótidos
/
Nucleótidos de Adenina
/
Infecciones por VIH
/
Síndrome de Inmunodeficiencia Adquirida
/
VIH-1
/
Receptores de Superficie Celular
/
Proteínas de Escherichia coli
Límite:
Humans
Idioma:
En
Revista:
Prog Mol Subcell Biol
Año:
1994
Tipo del documento:
Article
País de afiliación:
Alemania