Synaptotagmin I is essential for Ca(2+)-independent release of neurotransmitter induced by alpha-latrotoxin.
FEBS Lett
; 353(3): 315-8, 1994 Oct 24.
Article
en En
| MEDLINE
| ID: mdl-7957883
ABSTRACT
alpha-Latrotoxin causes massive release of norepinephrine from clonal rat pheochromocytoma PC12 cells, in the absence of external Ca2+, by an unknown mechanism. The effect almost disappeared in PC12 variant cells deficient in synaptotagmin I, a synaptic vesicle protein, and was rescued by transfecting the synaptotagmin I gene. These results indicate that synaptotagmin I is essential for the Ca(2+)-independent action of alpha-latrotoxin in PC12 cells.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Venenos de Araña
/
Proteínas de Unión al Calcio
/
Glicoproteínas de Membrana
/
Norepinefrina
/
Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón