Prognostic significance of flow cytometry deoxyribonucleic acid analysis of human oligodendrogliomas.
Neurosurgery
; 34(4): 680-7; discussion 687, 1994 Apr.
Article
en En
| MEDLINE
| ID: mdl-8008167
Flow cytometry was used to determine the deoxyribonucleic acid ploidy and proliferative activity of 60 oligodendrogliomas and oligoastrocytomas. The relationships among survival, ploidy, proliferation, histological features, and clinical variables were analyzed. Survival was strongly associated with the S-phase fraction (P < 0.001). Three groups with significantly different survival rates were defined, based on S-phase fraction ranges of < 3%, 3 to 5.9%, and > 6%. Significant associations between survival and age at diagnosis (P < 0.001), tumor grade (P < 0.001), and extent of surgery (P < 0.01) were found also. The poor correlation between mitotic figures and survival in oligodendrogliomas that has been reported previously emphasizes the need for an accurate method to measure proliferative activity. Our study demonstrated the usefulness of the flow cytometry-determined S-phase fraction in this regard and demonstrated that specific reference ranges could be defined for clinical application. In contrast, the determination of ploidy by flow cytometry was not useful in the evaluation of oligodendrogliomas.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Oligodendroglioma
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Ploidias
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Neoplasias Encefálicas
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ADN de Neoplasias
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Citometría de Flujo
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Glioma
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neurosurgery
Año:
1994
Tipo del documento:
Article