Predominant role of the substituents on the hydroxyl groups of 3-hydroxy fatty acids of non-reducing glucosamine in lipid A for the endotoxic and antagonistic activity.
FEBS Lett
; 351(3): 325-9, 1994 Sep 12.
Article
en En
| MEDLINE
| ID: mdl-8082789
ABSTRACT
The synthetic disaccharide precursor of lipid A (406 identical to lipid IVA) was found to reduce its endotoxic activity in mice by an order of 10(5) or more, by replacing the hydroxyl groups with succinyl or acetyl residues. Both the succinylated and acetylated 406 were also found to antagonize the endotoxic mitogenicity on murine splenocytes. Previous studies demonstrated that the succinylated or acetylated synthetic complete lipid A preparations retained the whole endotoxic activity [1994, Infect. Immunol. 62, 1705]. The drastic contrast in all of these results suggests the importance of the substituents on the hydroxyl groups of 3-hydroxy fatty acids of non-reducing glucosamine of lipid A for the activity and for transformation to the antagonistic structure.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Endotoxinas
/
Ácidos Grasos
/
Glucosamina
/
Lípido A
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón