Statistical analysis of data in mutagenicity assays: rodent micronucleus assay.
Environ Health Perspect
; 102 Suppl 1: 49-52, 1994 Jan.
Article
en En
| MEDLINE
| ID: mdl-8187724
ABSTRACT
To evaluate chemical safety, many kinds of short-term mutagenicity assays are performed together with long-term assays in animals. Rationales and methodology for these assays have been well discussed and documented. No statistical method, however, has been singled out as the method of choice for the evaluation of mutagenicity assay data, although a number of reports on statistical methods to evaluate such data have been published. Among the mutagenicity assays, the micronucleus assay using mouse bone marrow erythropoietic cells have been widely used to assess cytogenetic activities of test chemicals. A statistical evaluation procedure for this assay is proposed herein, combining the use of historical control data and dose-response relationships. The probability of type I errors and the power of this method are compared with those of some other conventional methods by Monte Carlo simulation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pruebas de Micronúcleos
/
Interpretación Estadística de Datos
/
Pruebas de Mutagenicidad
Tipo de estudio:
Health_economic_evaluation
Límite:
Animals
Idioma:
En
Revista:
Environ Health Perspect
Año:
1994
Tipo del documento:
Article
País de afiliación:
Japón