Immune response in mice that lack the interferon-gamma receptor.
Science
; 259(5102): 1742-5, 1993 Mar 19.
Article
en En
| MEDLINE
| ID: mdl-8456301
ABSTRACT
Interferon-gamma (IFN-gamma) exerts pleiotropic effects, including antiviral activity, stimulation of macrophages and natural killer cells, and increased expression of major histocompatibility complex antigens. Mice without the IFN-gamma receptor had no overt anomalies, and their immune system appeared to develop normally. However, mutant mice had a defective natural resistance, they had increased susceptibility to infection by Listeria monocytogenes and vaccinia virus despite normal cytotoxic and T helper cell responses. Immunoglobulin isotype analysis revealed that IFN-gamma is necessary for a normal antigen-specific immunoglobulin G2a response. These mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Interferón gamma
/
Receptores de Interferón
/
Inmunidad
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1993
Tipo del documento:
Article
País de afiliación:
Suiza