Tolerance induction during ontogeny. I. Presence of active suppression in mice rendered tolerant to human gamma-globulin in utero correlates with the breakdown of the tolerant state.
J Exp Med
; 149(5): 1134-51, 1979 May 01.
Article
en En
| MEDLINE
| ID: mdl-87485
ABSTRACT
A specific state of T- and B-cell tolerance to human gamma-globulin (HGG) was induced in utero by intravenous administration of the deaggregated antigen to pregnant BALB/cCr mice. Tolerance persisted in the offspring until the 12th-wk of age and then began to gradually disappear. Suppressor cells could only be found when responsiveness to HGG ultimately appeared in the in utero-treated animals but not when they were completely unresponsives. In contrast, HGG-specific suppressors found in animals made unresponsive to HGG as adults appear to be associated with either the establishment and/or maintenance of the unresponsive state. To the extent that these experiments are consistent with natural self-tolerance to a serum protein, we conclude that active suppression is not a prerequisite from maintenance of unresponsiveness to self.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Gammaglobulinas
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Linfocitos B
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Linfocitos T
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Feto
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Tolerancia Inmunológica
Límite:
Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
J Exp Med
Año:
1979
Tipo del documento:
Article