Induction of RANTES expression by astrocytes and astrocytoma cell lines.
J Neuroimmunol
; 71(1-2): 207-14, 1996 Dec.
Article
en En
| MEDLINE
| ID: mdl-8982121
ABSTRACT
The cellular infiltrate found during the acute phase of multiple sclerosis (MS) consists of monocytes and activated T cells, suggesting the presence of cell-specific chemotactic signals during the inflammatory response. We examined the ability of human astrocytoma cell lines, as well as primary human and rat astrocytes, to generate a specific member of the intercrine/chemokine family of cytokines, RANTES, when exposed to TNF-alpha, IL-1 beta and IFN-gamma. Astrocytoma cells as well as primary astrocytes produced RANTES upon incubation with TNF-alpha or IL-1 beta. IFN-gamma alone did not induce RANTES production by astrocytes, but it potentiated the effects of either TNF-alpha or IL-1 beta. Induction of RANTES by TNF-alpha was mediated by the p55 receptor since a specific anti-p55 antiserum mimicked the effect of TNF-alpha. These results indicate that human astrocytes are capable of generating a cell-specific chemokine that can account for the inflammatory cellular infiltrate observed during the acute phase of MS, in a process that is regulated by cytokines.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Astrocitos
/
Quimiocina CCL5
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Neuroimmunol
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos