Transient exposure to cytarabine increases peptide growth factor receptor expression and tumorigenicity of melanoma cells.
Anticancer Res
; 17(4A): 2369-75, 1997.
Article
en En
| MEDLINE
| ID: mdl-9252649
ABSTRACT
We have demonstrated that anticancer drugs at cytostatic concentrations enhance the expression and function of epidermal growth factor (EGF-R) and transferrin (TRF-R) receptors on human tumor cells. We hypothesized that these effects could represent a protective response of tumor cells to sublethal antiproliferative stimuli which could lead to enhanced growth potential. 72 hours exposure of human melanoma GLL-19 cells to 1,000 nM ara-C induced growth inhibition and increased the number of EGF-R, TRF-R and nerve growth factor receptor (NGF-R) on cell surface. Enhanced expression of beta 3 integrins CD49a, CD49c and CD49e, av integrin CD51, beta 3 integrin CD61, CD58/LFA3 and collagen IV and laminin was also detected in ara-C-treated GLL-19 cells. These changes at the tumor cell surface were paralleled by increased in vitro adhesion, invasive potential and clonogenic growth in soft agar and in vivo tumor formation. A more aggressive tumor cell phenotype is induced in human melanoma cells after transient exposure to cytostatic concentrations of ara-C.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Transferrina
/
Integrinas
/
Receptores de Factor de Crecimiento Nervioso
/
Citarabina
/
Receptores ErbB
/
Melanoma
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Anticancer Res
Año:
1997
Tipo del documento:
Article
País de afiliación:
Italia