Disruption of the mouse cyclooxygenase 1 gene. Characteristics of the mutant and areas of future study.
Adv Exp Med Biol
; 407: 87-92, 1997.
Article
en En
| MEDLINE
| ID: mdl-9321936
ABSTRACT
Surprisingly, disruption of the COX-1 gene resulted in generally healthy mice. This is in spite of the fact that prostaglandin levels in the tissues examined were reduced by greater than 99%. The results obtained to date with the COX-1 deficient mice indicate that some of the physiological roles previously attributed to COX-1 may not be entirely correct. Ongoing studies with the COX deficient mice are aimed at better defining the physiological roles of the cyclooxygenases and concomitantly the mechanisms by which NSAIDs cause their biological effects.
Buscar en Google
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Prostaglandina-Endoperóxido Sintasas
/
Isoenzimas
/
Ratones
Límite:
Animals
Idioma:
En
Revista:
Adv Exp Med Biol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos