Inhibition and enhancement of odorant-induced cAMP accumulation in rat olfactory cilia by antibodies directed against G alpha S/olf- and G alpha i-protein subunits.
FEBS Lett
; 426(3): 377-80, 1998 Apr 24.
Article
en En
| MEDLINE
| ID: mdl-9600270
ABSTRACT
The odorant-induced accumulation of cAMP can be inhibited by antibodies directed against G alpha s/olf. In contrast, antibodies raised against G alpha i-subunits caused a strong enhancement of the odorant-induced cAMP accumulation. Western blotting and immunoelectron microscopy revealed the presence of both G alpha s/olf- and G alpha i-subunits in rat cilia preparations. The existence of both stimulatory and inhibitory odorant-induced regulation of adenylyl cyclase activity in olfactory cilia may indicate that an initial integration of different odorant stimuli begins at the level of primary reactions in the same effector enzyme.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Mucosa Olfatoria
/
Receptores Odorantes
/
AMP Cíclico
/
Proteínas de Unión al GTP
/
Anticuerpos
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos