Comparison of p-fluoroketorolac and [18O3]ketorolac for use as internal standards for the determination of ketorolac by gas chromatography/mass spectrometry (GC/MS).
J Pharm Biomed Anal
; 17(2): 227-31, 1998 Jun.
Article
en En
| MEDLINE
| ID: mdl-9638574
ABSTRACT
A chemical and a stable-isotope analog, p-fluoroketorolac and [18O3]ketorolac respectively, were directly compared for applicability as internal standards for the determination of ketorolac in plasma samples using gas chromatography/mass spectrometry (GC/MS) with selective-ion-monitoring detection, following derivatization to form the methyl esters. This comparison involved analyzing ketorolac calibration standards and spiked plasma samples that contained both internal standard candidates. The response for ketorolac and each internal standard was monitored simultaneously and electronically integrated peak heights were obtained. Thus, for each analysis performed, a response ratio was obtained for each internal standard relative to an identical ketorolac response. Linearity of response for ketorolac calibration standards and accuracy for spiked plasma sample analysis were compared using each internal standard. The use of [18O3]ketorolac as the internal standard provided superior accuracy data for the analysis of ketorolac in plasma samples.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Tolmetina
/
Antiinflamatorios no Esteroideos
/
Analgésicos no Narcóticos
Idioma:
En
Revista:
J Pharm Biomed Anal
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos