Expression of spliced XBP-1 s and ADRP in kidney of diabetic rats / 临床与实验病理学杂志
Chinese Journal of Clinical and Experimental Pathology
; (12): 1371-1374, 2014.
Article
en Zh
| WPRIM
| ID: wpr-457956
Biblioteca responsable:
WPRO
ABSTRACT
Purpose To investigate the expression of XBP-1s and ADRP in kidney of diabetic rats. Methods Diabetic rat models were successfully established by intraperitoneal injection of STZ. After two months rats were sacrificed and XBP-1s and ADRP were de-tected by immunohistochemistry and Western blot. Results XBP-1s and ADRP were located in renal tubular cells and increased by a-bout 2. 017 times and 1. 544 times in comparison with normal control rats (P<0. 05). Moreover, it was shown that high expression of XBP-1s was commonly accompanied with increased ADRP by Pearson correlation analysis and the correlation coefficient was 0. 723 (P<0. 05). Conclusion The increased XBP-1s may cause the up-regulation of ADRP in the kidney of diabetic rats.
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Banco de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Clinical and Experimental Pathology
Año:
2014
Tipo del documento:
Article