Effects of losartan on apoptosis and expression of Fas and Fas-L in the kidney of diabetic rats / 中华肾脏病杂志
Chinese Journal of Nephrology
; (12)1997.
Article
en Zh
| WPRIM
| ID: wpr-552286
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate the effects of angiotensin II type I receptor antagonist losartan on apoptosis and the expression of Fas and Fas-L in the kidney of diabetic rats. Methods Uninephrectomized, STZ(65 mg/kg) -induced diabetic male SD rats were used. Losartan(40 mg/kg) was delivered daily by gavage from the next day of the induction to diabetes for 12 weeks. Apoptosis was examined by means of terminal-deoxynucleotidyl transferase mediated d-UTP nick end labeling(TUNEL) . Flow cytometry and immunohistochemistry were used to detect the expression of Fas and Fas-L. Results Compared with those in the kidneys of control group, apoptotic cells were more in number and the expression of Fas and Fas-L was higher in the diabetic kidneys( P
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Banco de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Nephrology
Año:
1997
Tipo del documento:
Article