Waldenstrom Macroglobulinemia with CD5+ Expression Presented as Cryoglobulinemic Glomerulonephropathy: A Case Report
Journal of Korean Medical Science
; : 824-828, 2011.
Article
en En
| WPRIM
| ID: wpr-58116
Biblioteca responsable:
WPRO
ABSTRACT
Waldenstrom macroglobulinemia (WM) is a B-cell lymphoproliferative disorder associated with bone marrow involvement of lymphoplasmacytic lymphoma (LPL) and an IgM monoclonal gammopathy. Generally B-lymphocytes in LPL do not express CD5 that is important for differential diagnosis of B-cell lymphoproliferative disorders. In WM, various renal diseases and type I cryoglobulinemia are well described separately, but cryoglobulinemic glomerulonephropathy is very rarely reported. A 61-yr-old woman complained of generalized edema, cyanosis of the extremities in cold weather, visual disturbance, and pancytopenia. Bone marrow and renal biopsy showed CD5+ expressing B-cells and cryoglobulinemic glomerulonephropathy. With the diagnosis of WM, she received cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy and got complete remission. Here, we report a rare case of WM associated with unusual expression of CD5+ B-lymphocytes and cryoglobulinemic glomerulonephropathy, and emphasize the importance of the clinical features in differentiating CD5+ B-cell lymphoproliferative disorders.
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Paraproteinemias
/
Vincristina
/
Médula Ósea
/
Prednisolona
/
Linfocitos B
/
Doxorrubicina
/
Macroglobulinemia de Waldenström
/
Antígenos CD5
/
Crioglobulinemia
/
Ciclofosfamida
Tipo de estudio:
Diagnostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Journal of Korean Medical Science
Año:
2011
Tipo del documento:
Article