Minimally Invasive Stereotactical Radio-ablation of Adrenal Metastases as an Alternative to Surgery / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 20-28, 2017.
Article
en En
| WPRIM
| ID: wpr-6998
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
The purpose of this study was to study the clinical outcome for patients with metastases of the adrenal gland treated with stereotactic body radiation therapy. MATERIALS ANDMETHODS:
Forty-six patients were studied retrospectively. The dose prescription was 40 Gy in four fractions. Dosimetric analysis was performed using the dose volume histograms while clinical outcome was assessed using actuarial analysis with determination of the overall survival (OS) and local control (LC) rates.RESULTS:
The planning objectives were met for all patients. With a median follow-up period of 7.6 months, at the last follow-up 42 patients (91.3%) were alive and four had died because of distant progression. The actuarial mean OS was 28.5±1.6 months, the median was not reached. One-year and 2-year OS were 87.6±6.1%. None of the risk factors was significant in univariate analysis. Actuarial mean LC was 14.6±1.8 months (95% confidence interval [CI], 11.0 to 18.2) and median LC was 14.5±2.0 months (95% CI, 10.5 to 18.5). One-year and 2-year LC were 65.5±11.9% and 40.7±15.8%, respectively. A mild profile of toxicity was observed in the cohort of patients. Forty patients (86.9%) showed no complication (grade 0); two patients reported asthenia, six patients (13.1%) reported either pain, nausea, or vomiting. Of these six patients, five patients (10.9%) were scored as grade 1 toxicity while one patient (2.2%) was scored as grade 2.CONCLUSION:
Stereotactic body radiation therapy treatment provided an adequate clinical response in the management of adrenal gland metastases.Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Astenia
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Vómitos
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Estudios Retrospectivos
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Factores de Riesgo
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Análisis Actuarial
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Estudios de Cohortes
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Estudios de Seguimiento
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Radiocirugia
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Glándulas Suprarrenales
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Radioterapia de Intensidad Modulada
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Cancer Research and Treatment
Año:
2017
Tipo del documento:
Article