Q-markers of Yuquan Capsules based on serum pharmacochemistry of Chinese medicine / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1802-1813, 2022.
Article
en Zh
| WPRIM
| ID: wpr-928176
Biblioteca responsable:
WPRO
ABSTRACT
This study analyzed the quality markers(Q-markers) of Yuquan Capsules(YQC) based on serum pharmacochemistry of Chinese medicine and detected the components and metabolites of YQC absorbed into the blood by UPLC-Q-TOF-MS and UNIFI systems. As a result, 32 components of YQC were detected, including 17 prototype components and 15 metabolized components. Among them, 12 prototype components(ginsenoside Rh_2, genistein, formononetin, puerarin, daidzein, schizandrin A, schizandrin B, schizandrin C, schizandrol A, schizandrol B, gomisin D, and ononin) and 12 metabolized components(ginsenoside Rg_1, ginsenoside Rg_2, ginsenoside Rg_3, ginsenoside Ro, 3'-methoxypuerarin, daidzin, astragaloside Ⅱ, astragaloside Ⅳ, glycyrrhizic acid, liquiritigenin, isoliquiritin, and verbascoside) showed inhibitory effects and pharmacological activities against diabetes, and these 24 blood-entering components against diabetes were identified as Q-markers of YQC.
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Cápsulas
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Medicamentos Herbarios Chinos
/
Cromatografía Líquida de Alta Presión
/
Ginsenósidos
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Suero
/
Medicina Tradicional China
Tipo de estudio:
Diagnostic_studies
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2022
Tipo del documento:
Article