TET2 is upregulated during erythroid differentiation of CD34+ cells from healthy donors and myelodysplastic syndrome patients
Appl. cancer res
; 37: 1-4, 2017. tab, ilus
Article
em En
| LILACS, Inca
| ID: biblio-914823
Biblioteca responsável:
BR30.1
ABSTRACT
Background:
Tet methylcytosine dioxygenase 2 (TET2) is frequently mutated and/or downregulated in myeloid neoplasm, including myelodysplastic syndromes. Despite the extensive studies, the specific contribution of TET2 in disease phenotype of myeloid neoplasms is not fully elucidated. Recent findings have grown attention on the role of TET2 in normal and malignant erythropoiesis.Methods:
In the present study, we investigated TET2 mRNA levels by quantitative PCR during erythropoietin-induced erythroid differentiation CD34+ cells from healthy donor and myelodysplastic syndrome patients. Statistical analyses were performed using the ANOVA and Bonferroni post hoc test and a p-value <0.05 was considered statically significant.Results:
TET2 expression is upregulated during erythroid differentiation of CD34+ cells from healthy donor and myelodysplastic syndrome patients.Conclusions:
Our findings corroborate that TET2 is involved in the erythrocyte differentiation (AU)Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
/
Inca
Assunto principal:
Síndromes Mielodisplásicas
/
Antígenos CD34
/
Eritropoese
Limite:
Aged
Idioma:
En
Revista:
Appl. cancer res
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Brasil