Early human infection with Onchocerca volvulus is associated with an enhanced parasite-specific cellular immune response
J Infect Dis
; 183(11): [1662-8], Jun 1, 2001.
Article
em En
| ECUADOR
| ID: equ-6977
Biblioteca responsável:
EC107
Localização: Pubmed
ABSTRACT
The immune response after early exposure to or infection with Onchocerca volvulus was investigated in an autochthonous focus caused by the migration of infected persons to a previously unaffected area in Ecuador. Peripheral blood mononuclear cell (PBMC) proliferative and cytokine responses (interferon [IFN]-gamma and interleukin [IL]-5) to filarial antigens were measured in 14 subjects with serologic evidence of exposure and in 7 subjects with evidence of dermal microfilarial DNA and were compared with responses in 43 subjects with chronic O. volvulus infections. PBMC proliferative and cytokine responses (IFN-gamma and IL-5) to parasite antigens were elevated in the early exposure/infection group, compared with those in the chronic infection group. Addition of an IL-10-neutralizing antibody to filaria antigen-stimulated cultures resulted in significantly elevated proliferative responses in the chronic infection group. The findings suggest that early exposure and early parasite patency are associated with a vigorous cellular response, but, as infections become chronic, the cellular response becomes down-regulated, partly through an IL-10-dependent mechanism.(AU)
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Coleção BVS Equador:
Collection_ecuador
Base de dados:
ECUADOR
Assunto principal:
Autoimunidade
/
Onchocerca volvulus
Limite:
Humans
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2001
Tipo de documento:
Article