Differences in benzo(a)pyrene metabolism between rodent liver microsomes and embryonic cells.
Cancer Res
; 36(12): 4476-9, 1976 Dec.
Article
em En
| MEDLINE
| ID: mdl-1000495
ABSTRACT
Differences in benzo(a)pyrene metabolite pattern have been shown by rodent liver microsomes (Sprague-Dawley) and rodent embryo cells from Syrian hamsters and NIH Swiss mice. Rodent liver induced by methylcholanthrene shows marked quantitative variation between species. Additional pattern changes were found in mouse and hamster embryo secondary cultures with a reduction of the K-region metabolites and a marked increase in 9-hydroxybenzo(a)-pyrene. These results are indicative of a region-specific attack on the carcinogen by the cell monooxygenases which is distinct from the liver attack of microsomal enzymes on benzo(a)pyrene. These results suggest that activation and detoxification of benzo(a)pyrene may be species and tissue variable, and susceptibility and resistence to malignant transformation may be predicted on induction of a fortuitous combination of intermediate metabolic steps.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzopirenos
/
Microssomos Hepáticos
/
Embrião de Mamíferos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1976
Tipo de documento:
Article