Regional expression of mRNA encoding a second form of gonadotropin-releasing hormone in the macaque brain.
Endocrinology
; 140(4): 1945-8, 1999 Apr.
Article
em En
| MEDLINE
| ID: mdl-10098535
ABSTRACT
In mammals, reproduction is thought to be controlled by a single neuropeptide, gonadotropin-releasing hormone (GnRH-I), which regulates the synthesis and secretion of gonadotropins from the pituitary gland. However, another form of this decapeptide (GnRH-II), of unknown function, also exists in the brain of many vertebrate species, including humans; it is encoded by a different gene and its amino acid sequence is 70% identical to that of GnRH-I. Here we report the cloning of a GnRH-II cDNA from the rhesus macaque (Macaca mulatta), and show for the first time by in situ hybridization that GnRH-II mRNA is expressed in the primate midbrain, hippocampus and discrete nuclei of the hypothalamus, including the supraoptic, paraventricular, suprachiasmatic and arcuate. Because the regional distribution pattern of cells containing GnRH-II mRNA is largely dissimilar to that of cells containing GnRH-I mRNA, it is likely that these two cell populations receive distinct neuroendocrine inputs and thus regulate GnRH synthesis and release differently.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Química Encefálica
/
RNA Mensageiro
/
Expressão Gênica
/
Hormônio Liberador de Gonadotropina
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Macaca mulatta
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Endocrinology
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos