Thymic disorders and myasthenia gravis: genetic aspects.
Ann Med
; 31 Suppl 2: 46-51, 1999 Oct.
Article
em En
| MEDLINE
| ID: mdl-10574155
ABSTRACT
Myasthenia gravis (MG) is an autoimmune disease characterized by production of antibodies to acetylcholine receptor at the motor end-plate responsible for impairment of neuromuscular transmission. There is general agreement about the involvement of the thymus in the pathogenesis of MG, and thymic pathological changes are commonly found in MG patients. Genetic factors seem to play an important role in susceptibility to MG. As with other autoimmune diseases, genetic predisposition to MG probably involves multiple genes. Ample evidence suggests that genes within the major histocompatibility complex (MHC) are involved in susceptibility to autoimmune diseases. Both data from the literature and our findings indicate that different genes within the MHC could predispose to various forms of MG, and that particularly the tumour necrosis factor genes may play a role in the association between the different thymic disorders and MG.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Necrose Tumoral alfa
/
Complexo Principal de Histocompatibilidade
/
Miastenia Gravis
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ann Med
Assunto da revista:
MEDICINA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Itália